【摘要】目的：评价纳络酮 治疗 急性酒精中毒的临床疗效。 方法 ：将78例非糖尿病酒精中毒的患者随机分为两组，治疗组40例，对照组38例，两组在性别、年龄及病因等方面无差异性（P＞0.05）。两组均常规给予洗胃、补液，保护胃粘膜，制酸治疗。治疗组同时给予纳络酮0.4mg静推，严重患者间隔30min可重复使用1次，随后给予10%Gs250ml+纳络酮0.8mg静滴。结果：纳络酮治疗组患者症状改善，清醒时间明显提前于对照组。结论：纳络酮是治疗急性酒精中毒的安全有效的药物。
【关键词】纳络酮；急性酒精中毒； 疗效
Observing the Effect of Naloxone on Acute Alcoholism
ZHANG Tian-wen
(Internal Medicine Department, No. V Hospital, Anhui Wuhu 241000, China)
Abstract： Objective: To evaluate the clinical effect of naloxone on acute alcoholism. Method: 78 cases of non-diabetes alcoholism were randomly divided into two groups: the remedial group (40 cases) and the comparison group (38 cases). The re's no difference (P>0.05) in sex, age and cause of disease between two gronp. Both groups were given gastric lavage, fluid infusion, protection of mucous membrane of stomach and inhibition of gastric acid. The remedial group was given vEin infusion of 0.4mg Naloxone. The severe ones were given vEIn infusion again after 30 minutes. Then, vein instillation of 10%GS250ml + Naloxone0.8mg was given. Result: Symptoms of the remedial group were obviously improved. Consciousness was regained much earlier than that of the comparison group. Conclusion: Naloxone can be used effectively and safely in treating acute alcoholism.
Key words： Naloxone; Acute alcoholism; Effect
2003年至2006年我们 应用 盐酸纳络酮治疗急性酒精中毒40例患者，效果良好，现 总结 如下：
1 资料与方法
1.1 一般资料：按入院顺序将确诊的急性酒精中毒的患者随机分为2组，治疗组40例，男性30例，女性10例，年龄18～50岁，平均年龄31.5岁。处于兴奋期5例，处于共济失调期25例，处于昏睡昏迷期10例。对照组38例，男性29例，女性9例，年龄16～52岁，平均30.2岁，处于兴奋期4例，处于共济失调期24例，处于昏睡昏迷期10例。78例患者白酒的摄入量为2两至1斤。饮酒后就诊时间均在3h内。两组年龄、性别、饮酒量无显著差异性，具有可比性。
1.2 方法：在患者病情及插管条件许可下，应尽快给予插管洗胃，并注意保暖、输液、吸氧，保持呼吸道畅通，预防呕吐物吸入等。对照组给予10%GS500ml+vitc2.0+vitB60.2+肌苷0.4静滴，5%GS250ml+奥美拉唑40mg静滴，BES500ml静滴。治疗组在上述治疗的基础上加用纳络酮0.4mg静推，严重者间隔30min重复使用1次，随后给予10%GS250ml+纳络酮0.8mg静滴维持，直至病人完全清醒，全部患者每30min记录呼吸、血压、脉搏、神志、尿量情况，记录确切清醒时间。
转贴于论文联盟 http://www.lwlm.com
【关键词】纳络酮；急性酒精中毒； 疗效
Observing the Effect of Naloxone on Acute Alcoholism
ZHANG Tian-wen
(Internal Medicine Department, No. V Hospital, Anhui Wuhu 241000, China)
Abstract： Objective: To evaluate the clinical effect of naloxone on acute alcoholism. Method: 78 cases of non-diabetes alcoholism were randomly divided into two groups: the remedial group (40 cases) and the comparison group (38 cases). The re's no difference (P>0.05) in sex, age and cause of disease between two gronp. Both groups were given gastric lavage, fluid infusion, protection of mucous membrane of stomach and inhibition of gastric acid. The remedial group was given vEin infusion of 0.4mg Naloxone. The severe ones were given vEIn infusion again after 30 minutes. Then, vein instillation of 10%GS250ml + Naloxone0.8mg was given. Result: Symptoms of the remedial group were obviously improved. Consciousness was regained much earlier than that of the comparison group. Conclusion: Naloxone can be used effectively and safely in treating acute alcoholism.
Key words： Naloxone; Acute alcoholism; Effect
2003年至2006年我们 应用 盐酸纳络酮治疗急性酒精中毒40例患者，效果良好，现 总结 如下：
1 资料与方法
1.1 一般资料：按入院顺序将确诊的急性酒精中毒的患者随机分为2组，治疗组40例，男性30例，女性10例，年龄18～50岁，平均年龄31.5岁。处于兴奋期5例，处于共济失调期25例，处于昏睡昏迷期10例。对照组38例，男性29例，女性9例，年龄16～52岁，平均30.2岁，处于兴奋期4例，处于共济失调期24例，处于昏睡昏迷期10例。78例患者白酒的摄入量为2两至1斤。饮酒后就诊时间均在3h内。两组年龄、性别、饮酒量无显著差异性，具有可比性。
1.2 方法：在患者病情及插管条件许可下，应尽快给予插管洗胃，并注意保暖、输液、吸氧，保持呼吸道畅通，预防呕吐物吸入等。对照组给予10%GS500ml+vitc2.0+vitB60.2+肌苷0.4静滴，5%GS250ml+奥美拉唑40mg静滴，BES500ml静滴。治疗组在上述治疗的基础上加用纳络酮0.4mg静推，严重者间隔30min重复使用1次，随后给予10%GS250ml+纳络酮0.8mg静滴维持，直至病人完全清醒，全部患者每30min记录呼吸、血压、脉搏、神志、尿量情况，记录确切清醒时间。
转贴于论文联盟 http://www.lwlm.com
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